Wnt daily caps | gendvi.se
Wnt daily caps | gendvi.se Access to human pluripotent cells theoretically provides a renewable source of cells that can give rise to any required cell type for use in cellular therapy or bioengineering. However, successfully directing this differentiation remains challenging for most desired endpoints cell type, including renal cells. This challenge wnt compounded by the difficultly in identifying the required cell type in vitro and the multitude of renal cell types required to build a kidney. Here we review our understanding of how the embryo goes about specifying the cells of the kidney and the progress to date in adapting this knowledge for the recreation of nephron progenitors and their mature derivatives from pluripotent cells. The kidney is a complex organ with a highly constrained architecture and more than 20 distinct mature cellular phenotypes, all of which are required for this organ to regulate fluid balance, nitrogenous waste removal, acid-base homeostasis, haematocrit and bone density.